Pathological fracture cancer8/18/2023 ![]() ![]() Recent advances in diagnostic and therapeutic capabilities have resulted in a better prognosis in many cancer patients. This can guide specialist management and offer patients a more accurate expectation of functional outcome and survival time.Īs the average life expectancy has increased, so too has the prevalence of cancer. ConclusionĪ novel scoring system has been developed that offers a survival probability based on patient’s individual circumstances. There was a statistically significant association between patient survival and primary cancer type, physical functional score, spinal metastatic burden and use of chemotherapy or radiotherapy. Median time from cancer diagnosis to pathological fracture was 14.2 months. Median survival from fracture to death was 4.1 months. ResultsĪ total of 233 patients were included. Variables assessed were primary cancer type, fracture site, fixation method, cement augmentation, pre-morbid level of physical functioning, complication rate, treatment with chemotherapy or radiotherapy and appendicular, spinal and visceral metastatic load. The records of all patients that presented with metastatic pathological fractures over a 10-year period from the only tertiary orthopaedic departments in Western Australia were retrospectively examined. The aim of this study was to identify the variables that influence prognosis and utilise these to develop a novel scoring system to better predict life expectancy post-pathological fracture. © 2014 Royal Australasian College of Surgeons.The most appropriate treatment of pathological fractures from metastatic disease depends on several factors, one of the most important being predicted life expectancy. ![]() We propose that these variables are scrutinized by the treating orthopaedic team preoperatively to help guide management and provide patients and their families with a realistic expectation of functional outcome and survival time.īone fractures neoplasm metastasis neoplasms pathologic processes prognosis spontaneous. Overall, the prognosis following pathological fracture is extremely poor. There is a statistically significant correlation between patient survival and primary cancer type, spinal metastatic burden and functional performance score. The median time between diagnosis of cancer to pathological fracture was 8.3 months, while the median survival post-fracture was 3.3 months. The variables of interest include primary cancer, fracture site, method of fixation, use of cement augmentation, appendicular metastatic load, spinal metastatic load, presence of visceral metastases, patient co-morbidities and functional scoring before and after the fracture has occurred. Retrospective clinical audit of 72 patients from the Orthopaedic Unit at Fremantle Hospital in Western Australia. This study investigates the variables affecting prognosis in patients suffering pathological fractures. Although several studies look into prognosis following the development of metastatic lesions, few look into the prognosis after the fracture itself. They are frequently a marker of end-stage cancer and the end of functional independence. Pathological fractures are a significant and often devastating event in the progression of metastatic bone disease.
0 Comments
Leave a Reply.AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |